Use of diabetes medications in non-approved (aka off-label) ways is increasingly common. This month, Amy and Liz dig into common off-label usage of Type 2 medications in insulin-deficient diabetes. Meds like GLP-1s, SLGT2’s, and metformin have an established history as a treatment for improving insulin sensitivity in T1’s. Ever wonder how that works and what the potential down sides are? While they’re on the topic of medications used for non-FDA-approved purposes, stay for the second half of the episode where they delve into use of supplements (cinnamon and turmeric) for diabetes management and if/how it works (the answer may surprise you) (or not).

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Reference Links

https://diatribe.org/how-people-diabetes-are-getting-during-ozempic-shortage

Off-Label Medication in T1D https://www.utsouthwestern.edu/newsroom/articles/year-2023/february-type-1-diabetes.html

GLP-1s in T1D https://www.endocrinologyadvisor.com/home/topics/diabetes/type-1-diabetes/type-1-diabetes-adjunct-insulin-therapy-glucagon-like-peptide-1-receptor-agonists-glp-1-ra/

Current and Therapeutic Use of Metformin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915435/

Metformin in T1D [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771191/#:~:text=Metformin reduces hepatic glucose production,20%2C 21%2C 26]](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771191/#:~:text=Metformin reduces hepatic glucose production,20%2C 21%2C 26])

https://www.sciencedirect.com/science/article/pii/S2589936821000049

Metformin as an anti-cancer med https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497052/#:~:text=Based on recent analyses and,prostate%2C colon%2C pancreas%2C and

TZDs in Diabetic Children and Beta Cell Preservation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890222/

TZDs Info https://dtc.ucsf.edu/types-of-diabetes/type2/treatment-of-type-2-diabetes/medications-and-therapies/type-2-non-insulin-therapies/insulin-sensitizers/

TZDs in T2 Treatment